ASIA unversity:Item 310904400/2470
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    題名: Expressions of Lymphotactin and Its Receptor XCR in Lewis Rats with Experimental Autoimmune Anterior Uveitis
    作者: Jim Lin
    貢獻者: Department of Biotechnology
    關鍵詞: Uveitis;Iris;Chemokine
    日期: 2005
    上傳時間: 2009-11-06 06:09:53 (UTC+0)
    出版者: Asia University
    摘要: Acute anterior uveitis (AAU) is the most common form of uveitis in humans and the exact mechanism of AAU has yet to be determined. We have successfully created an animal model of Experimental Autoimmune Anterior Uveitis (EAAU) in Lewis rat. In this experiment, we studied the expression of lymphotactin – a chemokine which attracts lymphocytes to inflammation sites in the EAAU. We observed that the leukocytes of aqueous humor increased with the severity of inflammation of iris/ciliary body. There were specific lymphotactin and its receptor messenger RNA expressions in iris/cilicary body in EAAU. The expression of lymphotactin receptor in iris/ciliary body correlated with that of lymphotactin. Furthermore, the lymphotactin protein levels of aqueous humor also correlated with the disease process. Pyrrolidine dithiocarbamate (PDTC), a nuclear factor kappa B inhibitor, markedly inhibited the expression of lymphotactin protein in the aqueous humor. Immunohistochemical staining revealed that lymphotactin was expressed on infiltrated inflammatory cells of iris/ciliary body. Flow cytometry analysis revealed that there was increasing number of CD8 + cytotoxic T cells with positive lymphotactin staining with the severity degree of inflammation. In conclusion, lymphotactin played an important role in the pathogenesis of EAAU and could attract more inflammatory cells to the iris/ciliary body.
    顯示於類別:[生物科技學系] 博碩士論文

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