The Chinese culture is broad and profound and the Chinese literati painting is one of the most representative one. The Zen thought is not only the religion but also the philosophy and esthetics. The influence of Zen’s esthetics on the Chinese literati painting is huge and profound. Computer animation has become one of the most important visual media that is ascribed to entertainment technology. The objective of this research is to apply the insight, found in the relationship between Zen and Chinese Literati, to computer-aided animation. Research has been done in the areas including juxtaposing historical articles, studying the characteristics revealed in Chinese Literati Painting, and analyzing the mentality of applying Zen to literal painting. To implement such animation, a series of creative experiments must be done based on working cohesively with the results arisen from the theoretical analysis. This research creates a 3D short animation short film----“唯畫通禪”, taking Zen’s esthetics as the performance style and the connotation. This animation uses landscape and flower-and-bird as the main composition elements, the Chinese literati painting as the main composition, and black and white as the tone.