With the development of information technology, computer games have provided various genres for the players to choose. Nowadays, the game players not only care how to operate a game, but also care the interaction with other players. Interaction is an intrinsic part of a game. The ways of interaction had also been transferred from interaction between players, interaction between human and machines, to interaction between players over the internet. Similarly, the interaction of computer game for the handicapped should be seriously considered so that such players can also immerse in the game playing. In this study, the usability of audio-only computer games for the visually impaired was discussed. Experiments with mixing the visually impaired and general players were conducted to compare the differences. Our results showed that audio-only game could enhance the quality of interactivity for the visually impaired. Playing games with mixing the visually impaired and general users could also get a higher entertainment. It is believed that this study would promote the understanding of general people to the visually impaired, and make them closer to each other.