Magnolol protects cortical neuronal cells from chemical hypoxia in rats

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题名:	Magnolol protects cortical neuronal cells from chemical hypoxia in rats
作者:	Min-Min Lee;Ming-Tsueh Hseih;Jon-Son Kuo;Feng-Tsgh Yeh;Hsueh-Meei Huang
贡献者:	保健營養生技學系
日期:	1998-10
上传时间:	2009-11-04 08:48:08 (UTC+0)
摘要:	THE protective effect of magnolol, a component of Magnolia officinalis, against hypoxia-induced cell injury in cortical neuron-astrocyte mixed cultures was examined. Exposure of the cells to chemical hypoxia (0.5 mM KCN) produced morphological changes in neurons but not in astrocytes. KCN induced dose- and time-dependent increases in release of LDH and decreases in viable cell number. Treatment with magnolol (10 and 100 μM) significantly reduced the KCN-induced LDH release in a concentration-dependent manner. A higher concentration (750 μM) magnolol was toxic. Nuclear condensation was not observed in KCN-treated cells, suggesting that chemical hypoxia-induced cell death was via necrosis, rather than via apoptosis. This is the first report demonstrating that magnolol protects neurons against chemical hypoxic damage or necrotic cell death in cortical neuron-astrocyte mixed cultures.
關聯:	Neuroreport; 9(15):3451-6.
显示于类别:	[食品營養與保健生技學系] 期刊論文

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