Preparation of polypeptide via living polymerization of Z-Lys-NCA initiated by platinum complexes

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题名:	Preparation of polypeptide via living polymerization of Z-Lys-NCA initiated by platinum complexes
作者:	Ya-Liu Peng;Shu-Ling Lai;Chu-Chieh Lin
贡献者:	數位媒體設計學系
日期:	2008-03
上传时间:	2012-11-26 07:22:27 (UTC+0)
摘要:	Two novel platinum complexes, [bis(diphenylphosphino)ethane][N-((1S,2R)-2-hydroxo-1,2-diphenylethyl)-4-methyl-benzenesulfonamidato]platinum(II) [(dppe)Pt(MBS-O), 2a] and [bis(diphenylphosphino)-ethane][N-((1S,2R)-2-amido-1,2-diphenylethyl)-4-methylbenzenesulfonamidato]platinum [(dppe)Pt(MBS-NH), 2b]were synthesized and structurally characterized. Experimental results show that compound 2b is an efﬁcient initiator toward ring opening polymerization of amino acid N-carboxyanhydride (NCA) yielding polypeptides with narrow PDIs (1.07-1.19). By comparing the activity of complex 2a with that of 2b, the mechanism for polymerization of NCA initiated by an amido-sulfonamidate is proposed.
關聯:	MACROMOLECULES,41:3455-3459.
显示于类别:	[數位媒體設計學系] 期刊論文

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