The purpose of this study was to explore the dual influences of work stressors and leisure on job satisfaction, work performance and absenteeism. Three work stressors were assessed, namely: “work demand”, “interpersonal conflict” and “lack of autonomy”. The purposive sampling method was used to conduct surveys with structured questionnaires among full-time workers in Taiwan. A total of 310 participants returned valid responses for further analysis. Our results showed that interpersonal conflict and lack of autonomy had negative impacts on job satisfaction. Lack of autonomy also had a negative impact on work performance. In addition, interpersonal conflict had a positive impact on absenteeism. We also found that leisure satisfaction could predict job satisfaction, work performance, and absenteeism, even after effects of work stressors were controlled. Finally, we noted that sports and social activities as leisure were the most beneficial to work performance.