ASIA unversity:Item 310904400/17994
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    题名: Whole Pelvic Helical Tomotherapy for Locally Advanced Cervical Cancer: Technical implementation of IMRT with Helical Tomothearapy
    作者: Chen-Hsi Hsieh;Ming-Chow Wei;Hsing-Yi Lee;Sheng-Mou Hsiao;Chien-An Chen;Li-Ying Wang;Yen-Ping Hsieh;Tung-Hu Tsai;Yu-Jen Chen;Pei-Wei Shueng
    贡献者: 健康產業管理學系
    日期: 2009-12
    上传时间: 2012-11-26 04:06:23 (UTC+0)
    摘要: Background
    To review the experience and to evaluate the treatment plan of using helical tomotherapy (HT) for the treatment of cervical cancer.
    Methods
    Between November 1st, 2006 and May 31, 2009, 10 cervical cancer patients histologically confirmed were enrolled. All of the patients received definitive concurrent chemoradiation (CCRT) with whole pelvic HT (WPHT) followed by brachytherapy. During WPHT, all patients were treated with cisplatin, 40 mg/m2 intravenously weekly. Toxicity of treatment was scored according to the Common Terminology Criteria for Adverse Events v3.0 (CTCAE v3.0).
    Results
    The mean survival was 25 months (range, 3 to 27 months). The actuarial overall survival, disease-free survival, locoregional control and distant metastasis-free rates at 2 years were 67%, 77%, 90% and 88%, respectively. The average of uniformity index and conformal index was 1.06 and 1.19, respectively. One grade 3 of acute toxicity for diarrhea, thrombocytopenia and three grade 3 leucopenia were noted during CCRT. Only one grade 3 of subacute toxicity for thrombocytopenia was noted. There were no grade 3 or 4 subacute toxicities of anemia, leucopenia, genitourinary or gastrointestinal effects. Compared with conventional whole pelvic radiation therapy (WPRT), WPHT decreases the mean dose to rectum, bladder and intestines successfully.
    Conclusion
    HT provides feasible clinical outcomes in locally advanced cervical cancer patients. Long-term follow-up and enroll more locally advanced cervical carcinoma patients by limiting bone marrow radiation dose with WPHT technique is warranted.
    關聯: Radiation Oncology,4:62.
    显示于类别:[健康產業管理學系] 期刊論文

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