ASIA unversity:Item 310904400/17469
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    請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/17469


    題名: Puerarin Acts Through Brain Serotonergic Mechanisms to Induce Thermal Effects.
    作者: Fu-Shin Chueh;Ching-Ping Chang;Chung-Ching Chio;Mao-Tsun Lin
    貢獻者: 保健營養生技學系
    關鍵詞: fever;hypothermia, serotonin;puerarin;hypothalamus
    日期: 2004-12
    上傳時間: 2012-11-26 02:33:17 (UTC+0)
    摘要: The present study was attempted to investigate the effect of puerarin, an isoflavone compound isolated from Pueraria lobata, on both the basal body temperature and pyrogenic fever in unanesthetized, restrained rats. Intraperitoneal administration of puerarin or crude extracts of Pueraria lobata elicited hypothermia. Direct administration of a small amount of puerarin into the lateral cerebral ventricle produced the same extent of hypothermia. Systemic or central administration of puerarin causes a decrease in both colonic temperature and hypothalamic 5-HT efflux in rats. The puerarin-induced hypothermia and decreased 5-HT efflux in the hypothalamus were attenuated by selective depletion of hypothalamic 5-HT produced by intracerebroventricular injection of 5,7-dihydroxytryptamine. Furthermore, the puerarin-induced hypothermia was almost completely abolished by treatment with a 5-HT2A-receptor agonist (DOI or quipazine) or a 5-HT1A-receptor antagonist [(−)-pindolol]. A 5-HT2A-receptor antagonist (ketanserin) or a 5-HT1A-receptor agonist (8-OH-DPAT) had additive effects with puerarin. Intracerebroventricular administration of interleukin-1 caused an increase in both colonic temperature and hypothalamic 5-HT efflux. The interleukin-1-induced hyperthermia and increased 5-HT efflux in the hypothalamus were attenuated by treatment with systemic administration of puerarin. The data indicate that puerarin exerts its hypothermic and antipyretic effects by activating 5-HT1A receptor and/or antagonizing 5-HT2A receptors in the hypothalamus.
    關聯: JOURNAL OF PHARMACOLOGICAL SCIENCES, 94(4):420-427.
    顯示於類別:[食品營養與保健生技學系] 期刊論文

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