Effect of Cholestin on toxicity of vitamin A in rats

ASIAIR > College of Medical and Health Science > Department of Food Nutrition and Healthy Biotechnology > Journal Article > Item 310904400/17455

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17455

Title:	Effect of Cholestin on toxicity of vitamin A in rats
Authors:	Yen-Hung Yeh;Ya-Ting Lee;You-Liang Hsieh
Contributors:	保健營養生技學系
Keywords:	Vitamin A;Cholestin;Toxicity;Hepatotoxicity;Nephrotoxicity
Date:	2012-05
Issue Date:	2012-11-26 02:33:09 (UTC+0)
Abstract:	A study was undertaken to investigate the effect of cholestin on the toxicity of vitamin A in male wistar rats. The rats were divided into six groups and fed different diets with or without supplement of 1% cholestin and 25,000–50,000 (IU) vitamin A for 2 months. Hence, the symptoms of vitamin A toxicity in rats included loss of body weight, hepatotoxicity and nephrotoxicity. However, these toxic effects of vitamin A were significantly reduced when the rats fed a diet supplemented with cholestin. Furthermore, the level of vitamin A in the serum of rats treated with cholestin and vitamin A was higher than that of the rats treated with vitamin A alone. It indicated that cholestin might play a role in reducing the toxic effect of vitamin A in rats.
Relation:	FOOD CHEMISTRY, 132(1):311-318.
Appears in Collections:	[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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