Chemical compositions, Anti-inflammatory, Antiproliferative and Radical-scavenging Activities of the methanol extracts of Actinidia callosa var. ephippioides

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/17414

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Title:	Chemical compositions, Anti-inflammatory, Antiproliferative and Radical-scavenging Activities of the methanol extracts of Actinidia callosa var. ephippioides
Authors:	Liao, Jung-Chun;Deng, Jeng-Shyan;Chiu, Chuan-Sung;Huang, Shyh-Shyun;Hou, Wen-Chi;Lin, Wang-Ching;Huang, Guan-Jhong
Contributors:	保健營養生技學系
Keywords:	Actinidia callosa var. ephippioides;Antioxidant Activity;Anti-Inflammatory Activity;Antiproliferation
Date:	2012-09
Issue Date:	2012-11-26 02:32:41 (UTC+0)
Abstract:	Oxidative stress and inflammation are related to several chronic diseases including cancer. Actinidia callosa var. ephippioides (ACE) is a special folk medicinal plant from Taiwan. The aim of this study is to evaluate the antioxidant, anti-inflammatory, and antiproliferative activities of the methanol extract and fractions from the stem of ACE. Trolox Equivalent Antioxidant Capacity (TEAC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, total phenolic content, flavonoid content, inhibition on nitric oxide (NO) productions by LPS-induced RAW264.7 cell, and on lung cancer cell proliferation were employed. Among all fractions, ethyl-acetate fraction (EA-ACE) showed higher TEAC, DPPH radical scavenging activities, polyphenol and flavonoid contents, respectively. EA-ACE also decreased the LPS-induced NO production and expressions of inducible nitric-oxide synthase (iNOS) in RAW264.7 cells. EA-ACE had the highest antiproliferative activity with an IC(50) (The concentrations required for inhibition of 50% of cell viability) of 469.17 ± 3.59 μg/mL. Catechin also had good effects in the antioxidant and anti-inflammatory activities. Catechin might be an important bioactive compound in the stem of ACE. The above experimental data indicated that the stem of ACE is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds.
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE
Appears in Collections:	[食品營養與保健生技學系] 期刊論文

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