Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice.

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題名:	Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice.
作者:	Guan-Jhong Huanga;Jeng-Shyan Dengb;Shyh-Shyun Huanga;Yi-Yuan Shaoc;Chin-Chu Chenc;Yueh-Hsiung Kuo
貢獻者:	保健營養生技學系
關鍵詞:	Chinese herb;Antrosterol;Anti-inflammation;MDA;NO;TNF-α
日期:	2012-05
上傳時間:	2012-11-26 02:32:38 (UTC+0)
摘要:	The hepatoprotective potential of antrosterol (ergostatrien-3β-ol, ST1) from Antrodia camphorata (AC) against carbon tetrachloride (CCl4)-induced liver damage was evaluated in preventive models in mice. Pretreatment with ST1 markedly prevented the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and liver lipid peroxides in CCl4-treated mice. The activities of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] were significantly increased after treatment with CCl4invivo. In addition, ST1 decreased the level of nitric oxide (NO) production and tumour necrosis factor-alpha (TNF-α) in CCl4-treated mice. In this study, these results pointed out that ST1 can inhibit lipid peroxidation, enhance the activities of antioxidant enzymes, decreases the TNF-α level, nitric oxide production and inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) expressions. Therefore, it was speculated that ST1 protects mice from liver damage through their anti-inflammation capacity.
關聯:	FOOD CHEMISTRY, 132(2):709-716.
顯示於類別:	[食品營養與保健生技學系] 期刊論文

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