Antioxidant and anti-inflammatory properties of Dichondra repens Forst. and its reference compounds

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/17409

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题名:	Antioxidant and anti-inflammatory properties of Dichondra repens Forst. and its reference compounds
作者:	鄧正賢;Deng, Jeng-Shyan;Sheu, MJ;Huang, MH;Liao, JC;Wu, CH;Huang, SS;Huang, GJ
贡献者:	保健營養生技學系
关键词:	Dichondra repens;Antioxidant;Anti-inflammation;NO;TNF-α;MDA
日期:	2012-05
上传时间:	2012-11-26 02:32:37 (UTC+0)
摘要:	Dichondra repens (DR) is the main constituent in herbal beverages and consumed daily as a nutrition supplement for the liver in Taiwan. This study investigated the antioxidant and anti-inflammatory effects of D. repens ethanol extract (EDR) and its reference compounds ex vivo and in vivo. Fingerprint chromatograms (from HPLC) indicated that EDR contained vanillin, umbelliferone and scopoletin. EDR was evaluated for its antioxidant effects and LPS-induced NO production in RAW 264.7 cells. EDR decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW 264.7 cells. In vivo anti-inflammatory activities of EDR were assessed in mouse paw oedema, induced by λ-carrageenan (Carr). We investigate the antioxidant mechanism of EDR via studies of the activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the liver and the levels of malondialdehyde (MDA) and nitrite oxide (NO) in the oedematous paw. Serum NO and TNF-α were also measured. EDR exerts anti-inflammatory effects by suppressing TNF-α, NO, and might be related to the decrement of the level of MDA in the oedema paw via increasing the activities of CAT, SOD and GPx in the liver. The results show that EDR might be a natural antioxidant and anti-inflammatory agent.
關聯:	FOOD CHEMISTRY, 132(2):1010-1018.
显示于类别:	[食品營養與保健生技學系] 期刊論文

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