Effects of protocatechuic acid on trans fat induced heaptic steatosis in mice

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/17356

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题名:	Effects of protocatechuic acid on trans fat induced heaptic steatosis in mice
作者:	Wen-Hu Liu;Chun-Che Lin;Zhi-Hong Wang;Mei-Chin Mong;Mei-Chin Yin
贡献者:	保健營養生技學系
关键词:	Trans fatty acid;protocatechuic acid;hepatic steatosis;stearoyl-CoA desaturase-1
日期:	2010-09
上传时间:	2012-11-26 02:31:55 (UTC+0)
摘要:	The effects of protocatechuic acid (PCA) on hepatic activity and/or mRNA expression of lipogenic enzymes and sterol regulatory element-binding proteins (SREBPs) in mice fed a trans fatty acid (TFA)-rich diet were examined. PCA at 1, 2, or 4% was provided for 10 weeks. Results showed that TFA diet significantly enhanced hepatic activity and mRNA expression of fatty acid synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, stearoyl-CoA desaturase-1, and SREBP-1c (P < 0.05); however, the intake of PCA significantly diminished the activity and mRNA expression of these lipogenic factors and decreased hepatic lipid accumulation (P < 0.05). TFA diet significantly increased hepatic levels of TFA and pro-inflammatory cytokines (P < 0.05). However, PCA intake significantly lowered hepatic content of 18:1 trans and 18:2 trans, as well as reduced the level of test cytokines (P < 0.05). These results indicate that PCA is a potent agent for attenuating TFA-induced hepatic steatosis.
關聯:	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58(18):10247-10252.
显示于类别:	[食品營養與保健生技學系] 期刊論文

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