Pyrrolizidine Alkaloids - Tumorigenic Components in Chinese Herbal Medicines and Dietary Supplements

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/17345

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題名:	Pyrrolizidine Alkaloids - Tumorigenic Components in Chinese Herbal Medicines and Dietary Supplements
作者:	PETER P. FU;YA-CHEN YANG;QINGSU XIA;M.W. CHOU;Y.Y. CUI;G. LIN
貢獻者:	保健營養生技學系
關鍵詞:	Pyrrolizidine alkaloids;Chinese herbal medicines;tumorigenecity
日期:	2002
上傳時間:	2012-11-26 02:31:47 (UTC+0)
摘要:	Traditional Chinese medicine (TCM) has long been used for treating illness in China and other Asian countries, and recently used by the Western countries in several different ways, either for new drug development, or as functional foods and dietary supplements. However, quality assurance and health adverse effects of the herbal plants have not been well studied. Pyrrolizidine alkaloids, a class of hepatotoxic and tumorigenic compounds, have been detected in herbal plants and dietary supplements. In this review, the sources of the pyrrolizidine alkaloid-containing Chinese herbal plants in China and the toxicity, genotoxicity, and tumorigenicity of these compounds are discussed. The metabolic pathways, particularly the activation pathways leading to genotoxicity, are discussed. Recent mechanistic studies indicate that pyrrolizidine alkaloids induce tumors via a genotoxic mechanism mediated by 6,7-dihydro-7-hydroxy-1-hydroxymethyl- 5H-pyrrolizine (DHP)-derived DNA adduct formation. This mechanism may be general to most carcinogenic pyrrolizidine alkaloids. Perspectives are included for suggestion of directions of future research.
關聯:	JOURNAL OF FOOD AND DRUG ANALYSIS, 10(4):198-211.
顯示於類別:	[食品營養與保健生技學系] 期刊論文

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