ASIA unversity:Item 310904400/17311
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    題名: Xylooligosaccharides and fructooligosaccharides affect the intestinal microbiota and precancerous colonic lesion development in rats
    作者: Cheng-Kuang Hsu;Jiunn-Wang Liao;Yun-Chin Chung;Chia-Pei Hsieh;Yin-Ching Chan
    貢獻者: 保健營養生技學系
    關鍵詞: prebiotic;xylooligosaccharides;fructooligosaccharides;bifidobacteria aberrant crypt foci
    日期: 2004-06
    上傳時間: 2012-11-26 02:31:21 (UTC+0)
    摘要: Certain nondigestible oligosaccharides can be selectively utilized by probiotics and reduce the risk
    of colon cancer. However, the inhibitory effects of xylooligosaccharides (XOS) on colon cancer are not well
    documented. This study evaluated the effects of xylooligosaccharides and fructooligosaccharides (FOS) on the
    alteration of cecal microbiota, cecal pH, cecal weight, and serum lipid levels, and also their inhibitory effect on
    precancerous colon lesions in male Sprague-Dawley rats. The rats were randomly assigned to 4 groups: control,
    treatment with 1,2-dimethylhydrazine (DMH) [15 mg/(kg body wt wk) for 2 wk], treatment with DMH 60 g
    XOS/kg diet, and treatment with DMH 60 g FOS/kg diet. Rats were fed the experimental diets for 35 d, beginning
    1wk after the second dose of DMH. Both XOS and FOS markedly decreased the cecal pH and serum triglyceride
    concentration, and increased the total cecal weight and bifidobacteria population. XOS had a greater effect on the
    bacterial population than did FOS. Moreover, both XOS and FOS markedly reduced the number of aberrant crypt
    foci in the colon of DMH-treated rats. These results suggest that XOS and FOS dietary supplementation may be
    beneficial to gastrointestinal health, and indicate that XOS is more effective than FOS.
    關聯: JOURNAL OF NUTRITION, 134(6):1523-1528.
    顯示於類別:[食品營養與保健生技學系] 期刊論文

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