ASIA unversity:Item 310904400/17302
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    题名: Vitamins B status and anti-oxidative defense in patients with chronic hepatitis B or hepatitis C virus infection
    作者: Chun-che Lin;Wen-hu Liu;Zhi-hong Wang;Mei-chin Yin
    贡献者: 保健營養生技學系
    关键词: Wild bitter gourd;PPARα;PPARγ;Adiponectin
    日期: 2011-09
    上传时间: 2012-11-26 02:31:14 (UTC+0)
    摘要: Background & Aims
    The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon B vitamins status and antioxidative defense in infected patients was examined.
    Methods
    Dietary record and blood levels of B vitamins and oxidative stress–associated biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV patients.
    Results
    HBV-infected patients had significantly higher levels of total cholesterol, free fatty acids (FFA), and lower ghrelin level (p < 0.05); and HCV-infected patients had significantly higher Ishak inflammation score and lactate dehydrogenase activity (p < 0.05). HBV patients had significantly lower red blood cell (RBC) vitamins B2 and B6 levels, and HCV infection significantly decreased vitamins B2, B6 and folate levels in RBC and/or plasma (p < 0.05). Correlation coefficients of RBC vitamin B2 versus serum FFA in HBV patients, RBC vitamins B2 and B6 versus HCV RNA and Ishak inflammation score, and plasma vitamin B6 vs Ishak inflammation score in HCV patients were <−0.5. HBV-infected patients had significantly higher oxidized glutathione level and lower glutathione peroxidase activity (p < 0.05), but HCV patients had significantly lower superoxide dismutase and catalase activities (p < 0.05).
    Conclusion
    HBV or HCV infection enhanced oxidative stress and lowered B vitamins in circulation. In order to avoid other healthy risk, nutrition status should be monitored and limitation or supplementation of certain nutrients might be helpful for HBV- or HCV-infected patients.
    關聯: EUROPEAN JOURNAL OF NUTRITION, 50(7):499-506.
    显示于类别:[食品營養與保健生技學系] 期刊論文

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