ASIA unversity:Item 310904400/17298
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 94286/110023 (86%)
Visitors : 21654713      Online Users : 1003
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17298


    Title: Association of dietary AGEs with circulating AGEs, glycated LDL, IL-1? and MCP-1 levels in type 2 diabetic patients
    Authors: Pei-chun Chao;Chien-ning Huang;Cheng-chin Hsu;Mei-chin Yin;Yu-ru Guo
    Contributors: 保健營養生技學系
    Keywords: Dietary AGEs;Glycated LDL;IL-1α;MCP-1
    Date: 2010-11
    Issue Date: 2012-11-26 02:31:12 (UTC+0)
    Abstract: Purpose: The association of dietary advanced glycation endproducts (AGEs) intake with the oxidative and inflammatory status in type 2 diabetic patients was examined. Methods: Seventy-four healthy controls, 50 low AGEs intake and 68 high AGEs intake type 2 diabetic patients were requested to complete a 7-day dietary record. Blood levels of several oxidative and inflammatory biomarkers were determined. Results: Diabetic patients with high AGEs intake had significantly elevated plasma levels of AGEs, HbA1c, low-density lipoprotein (LDL), LDL-cholesterol and glycated LDL than low AGEs intake patients and controls ( P < 0.05). These high AGEs intake patients also had significantly increased plasma levels of 8-isoprostane, interleukin (IL)-1a, tumor necrosis factor-a, monocyte chemoattractant protein (MCP)-1 and lower superoxide dismutase (SOD) activity than low AGEs intake patients ( P < 0.05). Correlation coefficients of dietary AGEs versus plasma AGEs, HbA1c, 8-isoprostane, IL-1a and MCP-1 were >0.6; but the correlation coefficient of dietary AGEs versus plasma SOD activity was <-0.6. Conclusion: Increasing dietary AGEs intake might enrich circulating AGE level and contribute to oxidative and inflammatory progression under diabetic condition. The circulating 8-isoprostane, IL-1a and MCP-1 levels and SOD activity might be appropriate biomarkers used to evaluate dietary AGEs-associated oxidative and inflammatory stress.
    Relation: EUROPEAN JOURNAL OF NUTRITION, 49(7):429
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML290View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback