ASIA unversity:Item 310904400/17242
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 94286/110023 (86%)
Visitors : 21693476      Online Users : 704
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/17242


    Title: Neuroprotective effect of luteolin on amyloid beta protein (25-35)-induced toxicity in cultured rat cortical neurons.
    Authors: 李明明;Lee, Min-Min
    Contributors: 保健營養生技學系
    Keywords: luteolin;Aβ;cortical neurons;MAP kinases;caspase 3
    Date: 2010-01
    Issue Date: 2012-11-26 02:30:27 (UTC+0)
    Abstract: The present study was carried out to investigate the neuroprotective effect of luteolin on amyloid β (Aβ) (25–35)-induced neurotoxicity using cultured rat cortical neurons. After exposure of primary cultures of rat cortical cells to 10 μm Aβ (25–35) for 48 h, cortical cell cultures exhibited marked apoptotic death. Pretreatment with luteolin (1, 10 μm) significantly protected cortical cell cultures against Aβ (25–35)-induced toxicity. Luteolin (1, 10 μm) showed a concentration-dependent inhibition on 10 μm Aβ (25–35)-induced apoptotic neuronal death, as assessed by MTT assay. Furthermore, luteolin reduced apoptotic characteristics by DAPI staining. For Western blot analysis, the results showed that the protective effect of luteolin on Aβ (25–35)-induced neurotoxicity was mediated by preventing of ERK-p, JNK, JNK-p, P38-p and caspase 3 activations in rat primary cortical cultures. Taken together, the results suggest that luteolin prevents Aβ (25–35)-induced apoptotic neuronal death through inhibiting the protein level of JNK, ERK and p38 MAP kinases and caspase 3 activations. Copyright © 2009 John Wiley & Sons, Ltd.
    Relation: PHYTOTHERAPY RESEARCH; 24 Suppl 1:S102-8. doi: 10.1002/ptr.2940.
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML361View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback