A circuit design of a low-cost, portable and programmable electroporation device

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Title:	A circuit design of a low-cost, portable and programmable electroporation device
Authors:	黃素華;Huang, Su-Hua;蕭進松;Hsiao, Chin-Sung;張剛鳴;Chang, Kang-Ming
Contributors:	生物科技學系
Keywords:	Electroporation;Low-cost;Programmable;Biomedical
Date:	2012-05
Issue Date:	2012-11-23 09:17:48 (UTC+0)
Abstract:	Electroporation for transdermal drug delivery or for non-invasive monitoring of patients could allow a new generation of medical devices to be developed for low-cost healthcare. The existing electroporation systems today are bulky, expensive or not fully programmable. Therefore, a compact, low-cost and programmable device was developed and evaluated. A circuit is described herein which provides a variety of adjustable high-voltage (2–300 V) electric waveforms (pulsed and pulsed-biphasic) for electroporation. Evaluation showed that this device provides for precise regulation of the magnitude and waveform of a high-voltage over a wide range of impedance, important for in vivo/human use. Also, the device was evaluated in vitro to be capable of enhancing transdermal extraction of metabolites, like uric acid, for non-invasive monitoring and transdermal delivery of medications, like insulin, for non-invasive drug delivery.
Relation:	Sensors and Actuators, B: Chemical
Appears in Collections:	[Department of Biotechnology] Journal Article

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