Synergistic anti-tumor activity of isochaihulactone and paclitaxel on human lung cancer cells

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/16808

請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/16808

題名:	Synergistic anti-tumor activity of isochaihulactone and paclitaxel on human lung cancer cells
作者:	余永倫;Yu, Yung-luen
貢獻者:	生物科技學系
日期:	2012-01
上傳時間:	2012-11-23 09:17:15 (UTC+0)
摘要:	Drug resistance frequently develops in tumors during chemotherapy. Therefore, to improve the clinical outcome, more effective and tolerable combination treatment strategies are needed. Here, we show that isochaihulactone (K8) enhanced paclitaxel-induced apoptotic death in human lung cancer cells, and the enhancing effect was related to increased NSAID-activated gene-1 (NAG-1) expression. CalcuSyn software was used to evaluate the synergistic interaction of K8 and paclitaxel on human lung cancer cells; the synergistic effect of K8 in combination with paclitaxel was increased more than either of these drugs alone. Furthermore, the activity of ERK1/2 was enhanced by the combination of K8 and paclitaxel, and an ERK1/2 inhibitor dramatically inhibited NAG-1 expression in human lung cancer cells. Therefore, this synergistic apoptotic effect in human lung cancer cells may be directly associated with K8-induced NAG-1 expression through ERK1/2 activation. Moreover, over-expression of NAG-1 enhanced K8/paclitaxel-induced apoptosis in human lung cancer cells. In addition, treatment of nude mice with K8 combined with paclitaxel induced phospho-ERK1/2 and NAG-1 expression in vivo. Targeting of NAG-1 signaling could enhance therapeutic efficacy in lung cancer. Our results reveal that activation of NAG-1 by K8 enhanced the therapeutic efficacy of paclitaxel in human lung cancer cells via the ERK1/2 signaling pathway.
關聯:	JOURNAL OF CELLULAR PHYSIOLOGY
顯示於類別:	[生物科技學系] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
9fcfd510899bad46d3.pdf		1158Kb	Adobe PDF	174	檢視/開啟

在ASIAIR中所有的資料項目都受到原著作權保護.

資料載入中.....