ncRNAppi - A tool for identifying disease-related miRNA and siR-NA targeting pathways

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题名:	ncRNAppi - A tool for identifying disease-related miRNA and siR-NA targeting pathways
作者:	吳家樂;Ng, Ka-Lok;劉學銓;Liu, Hsueh-Chuan;李尚熾;Lee, Shan-Chih
贡献者:	生物與醫學資訊學系
日期:	2009-09
上传时间:	2012-11-23 09:16:22 (UTC+0)
摘要:	"Summary: Currently, there are a number of databases which store microRNA (miRNA) information, and tools available which provide miRNA target prediction. In this paper we describe a novel web-based tool that integrate the miRNA-targeted mRNA data, protein-protein interactions (PPI) records, tissues, biochemical pathways, human disease and gene function information to establish a disease-related miRNA target pathway database. This database is unique in the sense that it links miRNA target genes with their PPI partners ac-cording to being tissue-specific, diseases-specific or both. The same approach is also applied to siRNA data. This database provides two types of searches; (i) tissue-specific, and (ii) disease-specific miRNA (or siRNA) targeting pathways. The search allows one to identify tissue-specific or disease-specific miRNA (or siRNA) target gene's PPI partners two levels beyond. The release version 1.0 is a freely accessible database available at"
關聯:	BIOINFORMATICS
显示于类别:	[生物資訊與醫學工程學系 ] 期刊論文

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