Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/16690

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题名:	Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis
作者:	萬磊;Wan, Lei;蔡輔仁;Tsai, Fuu-Jen;許晉銓;Sheu, Jim Jinn-Chyuan
贡献者:	生物科技學系
关键词:	oral squamous cell carcinoma (OSCC);Talin-1 (TLN1);9p13.3 amplicon;invasion
日期:	2011-07
上传时间:	2012-11-23 09:15:55 (UTC+0)
摘要:	Oral squamous cell carcinoma (OSCC) is highly invasive and is associated with frequent tumour recurrences and lymph node metastases. Identification of genes involved in the aggressiveness of OSCC may provide new targets for clinical intervention. A genome-wide study based on the Sty1 250K SNP array indicated the involvement of the Talin-1 (TLN1) gene in the 9p13.3 amplicon, which was further validated by dual colour fluorescence in situ hybridization (FISH). Comparative analyses revealed that TLN1 was the most highly expressed integrin-cytoskeleton cross-linker that can trigger integrin activation. IHC analyses and mouse study also revealed an association between TLN1 overexpression and advanced OSCC with invasion to adjacent tissues. Survival analyses indicated a significant association between TLN1 genetic gain/overexpression and a reduced overall survival in patients. Functional knockdown by a dominant negative TLN1 fragment reduced cell growth and invasiveness in TLN1-overexpressing cells via inactivation of downstream oncogenic signalling. The present study suggests an important role for TLN1 in oral cancer development. TLN1 overexpression could serve as a diagnostic marker for aggressive phenotypes and a potential target for treating OSCC. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
關聯:	JOURNAL OF PATHOLOGY
显示于类别:	[生物科技學系] 期刊論文

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