Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in taiwan chinese han population.

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Title:	Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in taiwan chinese han population.
Authors:	張培均;Chang, Pei-Chun
Contributors:	生物與醫學資訊學系
Keywords:	lumican, SLE, SNP, SLRP
Date:	2012
Issue Date:	2012-11-23 09:15:33 (UTC+0)
Abstract:	"OBJECTIVE: Lumican (LUM) is predominantly localized in areas of pathological fibrosis. To determine whether polymorphisms in LUM gene are associated with development of systemic lupus erythematosus (SLE), we analyzed 2 single-nucleotide polymorphisms (SNP) of LUM in a Taiwan Chinese Han population. METHODS: Participants included 168 patients with SLE and 192 age-matched controls in whom examinations had excluded SLE. Genotyping of -628 A/-(rs17018757) and c.1567 T/C polymorphisms in LUM were carried out in each patient and control using the polymerase chain reaction-restriction fragment-length polymorphism method, and validated by Taqman SNP genotyping assay. Data were correlated with the development of SLE and various clinical symptoms by chi-square analysis. RESULTS: Frequencies of C/C genotype and the C allele at c.1567 T/C were significantly higher in patients than controls. Polymorphism at c.1567 C/T was found to be associated with arthritis and photosensitivity in patients with SLE, which are both connective tissue-related symptoms. CONCLUSION: The c.1567 T/C polymorphism of LUM is related to the development and clinical symptoms of SLE."
Relation:	Turkish Journal of Rheumatology
Appears in Collections:	[Department of Biomedical informatics ] Journal Article

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