Applications of domain-domain interactions in pathway study

ASIA unversity > 資訊學院 > 生物資訊與醫學工程學系 > 期刊論文 > Item 310904400/16592

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題名:	Applications of domain-domain interactions in pathway study
作者:	吳家樂;Ng, Ka-Lok;劉湘川;Liu, Hsiang-Chuan
貢獻者:	生物與醫學資訊學系
關鍵詞:	Protein–protein interaction;Domain–domain interaction;Chemotaxis pathway;Blood coagulation pathway;MAPK pathway;Entropy
日期:	2008
上傳時間:	2012-11-23 09:14:53 (UTC+0)
摘要:	The domain combination pair approach is employed to derive putative protein domain–domain interactions (DDI) from the protein–protein interactions (PPI) database DIP. The results of putative DDI are computed for seven species. To determine the prediction performance, putative DDI results are compared with that of the database InterDom, where an average matching ratio of about 76% can be achieved. Several real PPI pathways are reconstructed based on the predicted DDI results. It is found that the pathways could be reconstructed with reasonable accuracy. Furthermore, a novel quantity, so called AP-order index, is introduced to predict the regulatory order for six PPI pathways. It is found that the AP-order index is a very reliable parameter to determine the regulatory order of PPI.
關聯:	Computational Biology and Chemistry,32(2),81-87.
顯示於類別:	[生物資訊與醫學工程學系 ] 期刊論文

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