Protein Structural Classes Prediction via Residues Environment Profile

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题名:	Protein Structural Classes Prediction via Residues Environment Profile
作者:	吳家樂;Ng, Ka-Lok
贡献者:	生物與醫學資訊學系
关键词:	protein classes;solvent accessible area;residue environment;protein structural profile.
日期:	2006
上传时间:	2012-11-23 09:14:41 (UTC+0)
摘要:	"We investigate how residue structural and physicochemical environment information, such as the protein secondary structure and residue solvent accessibility could be used for protein structural classes (all-alpha, all-beta, alpha/beta and alpha+beta) prediction. The residue environment information is described by the residue environment profiles which are derived from a relative small set of 500 protein sequences having a sequence identity less than 25%. It was demonstrated that this method is able to obtain an accuracy of 49.2% for a 4-type class prediction of monomeric and non-disulphide-bonded proteins, given the fact that none of the nonclassified protein sequences has a sequence identity higher than 25%. This result is comparable to the amino acid composition method which obtains an accuracy of 48% for a set of sequences having sequence similarity of less than 30%. The current approach has several advantages: (1) it is a physical approach, (2) there is no adjustable parameter, and (3) it is simple and efficient."
關聯:	ASIAN JOURNAL OF CONTROL
显示于类别:	[生物資訊與醫學工程學系 ] 期刊論文

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