ASIA unversity:Item 310904400/16444
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 94286/110023 (86%)
Visitors : 21692395      Online Users : 813
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/16444


    Title: E4BP4 is a cardiac survival factor and essential for embryonic heart development
    Authors: ;Weng, Yi-Jiun;Hsieh, Dennis Jine-Yuan;Kuo, Wei-Wen;Lai, Tung-Yuan;Hsu, Hsi-Hsien;Tsai, Chang-Hai;Tsai, Fuu-Jen;Lin, Ding-Yu;James, A.Lin;黃志揚;HUANG, CHIH-YANG;Tung, Kwong-Chung
    Contributors: 生物科技學系
    Keywords: E4BP4;Heart development;Cardiac survival factor
    Date: 2010-06
    Issue Date: 2012-11-23 09:13:11 (UTC+0)
    Abstract: The bZIP transcription factor E4BP4, has been demonstrated to be a survival factor in pro-B lymphocytes. GATA factors play important roles in transducing the IL-3 survival signal and transactivating the downstream survival gene, E4BP4. In heart, GATA sites are essential for proper transcription of several cardiac genes, and GATA-4 is a mediator of cardiomyocyte survival. However, the role E4BP4 plays in heart is still poorly understood. In this study, Dot-blot hybridization assays using Dig-labeled RNA probes revealed that the E4BP4 gene was expressed in cardiac tissue from several species including, monkey, dog, rabbit, and human. Western blot analysis showed that the E4BP4 protein was consistently present in all of these four species. Furthermore, immunohistochemistry revealed that the E4BP4 protein was overexpressed in diseased heart tissue in comparison with normal heart tissue. In addition, the overexpression of E4BP4 in vitro activated cell survival signaling pathway of cardiomyocytes. At last, siRNA-mediated knock down of E4BP4 in zebrafish resulted in malformed looping of the embryonic heart tube and decreased heart beating. Based on these results, we conclude that E4BP4 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development.
    Relation: MOLECULAR AND CELLULAR BIOCHEMISTRY; 340(1-2):187-94.
    Appears in Collections:[Department of Biotechnology] Journal Article

    Files in This Item:

    There are no files associated with this item.



    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback