Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells

ASIAIR > College of Medical and Health Science > Department of Biotechnology > Journal Article > Item 310904400/16426

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Title:	Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells
Authors:	許成光;Hsu, Cheng-Kuang;王建國;Wang, Chien-Kuo;張清堯;Chang, Ching-Yao
Contributors:	生物科技學系
Keywords:	Helicobacter pylori;Solanum lyratum;human gastric epithelial cells, apoptosis.
Date:	2010-04
Issue Date:	2012-11-23 09:12:55 (UTC+0)
Abstract:	"Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pyloriinduced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains. "
Relation:	ANTICANCER RESEARCH
Appears in Collections:	[Department of Biotechnology] Journal Article

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