A preliminary study of the use of bioimpedance

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Title:	A preliminary study of the use of bioimpedance
Authors:	Ching, Congo Tak-Shing;Sun, Tai-Ping;黃素華;Huang, Su-Hua;蕭進松;Hsiao, Chin-Sung;張清濠;Chang, Ching-Haur;黃秀園;Huang, Shiow-Yuan
Contributors:	生物科技學系
Keywords:	bioimpedance;tongue;cancer;noninvasive;detection;screening
Date:	2010-03
Issue Date:	2012-11-23 09:12:37 (UTC+0)
Abstract:	Oral cancers are the 11th most common malignancy reported worldwide, accountingfor 3% of all newly diagnosed cancer cases, and one with high mortality ratios among allmalignancies. The objective of this study was to study the electrical properties of canceroustongue tissue (CTT) and normal tongue tissue (NTT). Five tongue cancer patients participatedin this study. A disposable probe incorporating four silver electrodes was used to measure theelectrical properties of CTT and the surrounding NTT of patients. Measurements were performedat six frequencies: 20 Hz; 50 kHz; 1.3 MHz; 2.5 MHz; 3.7 MHz; and 5 MHz, with the amplitudeof the applied voltage limited to 200mV. Four measurement parameters of impedance (Z), phaseangle (θ), real part of impedance (R), and imaginary part of impedance (X) of tongue tissuewere assessed to see if there was any significant difference in the values obtained in CTT andsurrounding NTT. The intraclass correlation coefficient showed that all measurements werereliable. A significant difference (P  0.05 for the four measurement parameters) was foundat 50kHz between CTT and surrounding NTT. It was also found that Z and R of CTT weregenerally smaller than that of surrounding NTT. In conclusion, bioimpedance at a particularfrequency is a potentially promising technique for tongue cancer screening.Keywords: bioimpedance, tongue, cancer, noninvasive, detection, screening.
Relation:	International Journal of Nanomedicine,2010:5,213–220.
Appears in Collections:	[Department of Biotechnology] Journal Article

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