Curcumin Inhibits Human Lung Large Cell Carcinoma Cancer Tumour Growth in a Murine Xenograft Model

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/16391

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题名:	Curcumin Inhibits Human Lung Large Cell Carcinoma Cancer Tumour Growth in a Murine Xenograft Model
作者:	;Su, Chin-Cheng;楊家欣;Yang, Jai-Sing;呂啟誠;Lu, Chi-Cheng;江若華;Chiang, Jo-Hua;吳長霖;Wu, Chang-Lin;Lin, Jen-Jyh;賴光啟;Lai, Kuang-Chi;夏德椿;Hsia, Te-Chun;呂旭峰;Lu, Hsu-Feng;范宗宸;Fan, Ming-Jen;鍾景光;Chung, Jing-gung
贡献者:	生物科技學系
日期:	2010-01
上传时间:	2012-11-23 09:12:27 (UTC+0)
摘要:	Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo.
關聯:	PHYTOTHERAPY RESEARCH;Volume(24):189–192
显示于类别:	[生物科技學系] 期刊論文

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