Gandoderma lucidum Extract Promotes Immune Responses in Normal BALB/c Mice In Vivo

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Title:	Gandoderma lucidum Extract Promotes Immune Responses in Normal BALB/c Mice In Vivo
Authors:	張永賢;Chang, YH;楊家欣;Yang, JS;揚鈞隆;Yang, JL;吳長霖;Wu, CL;張淑貞;Chang, SJ;呂孔文;Lu, KW;郭昭麟;Kuo, CL;夏德椿;Hsia, TC;鍾景光;Chung, Jing-Gung
Contributors:	生物科技學系
Date:	2009-09
Issue Date:	2012-11-23 09:11:50 (UTC+0)
Abstract:	Enhanced fruit and vegetable consumption is closely related to reduced cancer incidence as shown in epidemiological studies. Ganoderma lucidum, one of the most well-known traditional Chinese medicines, has been demonstrated to have pharmacological activities and antitumor effects, in Asian populations. However, the promotion of immune responses in normal BALB/c mice is unclear. In the present study, we investigated the immune responses of BALB/c mice after treatment with G. lucidum extract in vivo. The results demonstrated that G. lucidum extract was able to promote the proliferation of splenocytes under Concanavalin A or lipopolysaccharide stimulation. Compared with the control group, phagocytosis of macrophage was significantly enhanced by intraperitoneal administration of G. lucidum extract at both 3 and 6 mg/kg. Compared with the control group, natural killer cell activity was significantly enhanced by intraperitoneal administration of G. lucidum extract (6 mg/kg). Results of cytometric bead array and flow cytometry indicated that the expressions of interleukin-6 and interferon-gamma also increased (p<0.001) by treatment with G. lucidum extract (3 and 6 mg/kg). In conclusion, the findings of this study implied that G. lucidum extract was able to effectively promote immune responses in BALB/c mice.
Relation:	IN VIVO, V.23 N.5:755-759.
Appears in Collections:	[生物科技學系] 期刊論文

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