Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model

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Title:	Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model
Authors:	何永?;Ho, YT;楊家欣;Yang, JS;呂啟誠;Lu, CC;江若華;Chiang, JH;李采娟;Li, TC;Lin, JJ;賴光啟;Lai, KC;廖慶隆;Liao, CL;林昭庚;Lin, JG;鍾景光;Chung, Jing-Gung
Contributors:	生物科技學系
Keywords:	Berberine;Human tongue SCC-4 cancer cells;Xenograft transplantation;In vivo
Date:	2009-09
Issue Date:	2012-11-23 09:11:47 (UTC+0)
Abstract:	Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10 mg/kg of body weight) and doxorubicin (4 mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4 mg/kg of doxorubicin or with 10 mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10 mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.
Relation:	PHYTOMEDICINE
Appears in Collections:	[Department of Biotechnology] Journal Article

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