Transcriptional and subcellular regulation of the TRIP-Br family

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/16252

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题名:	Transcriptional and subcellular regulation of the TRIP-Br family
作者:	;2.Lai, IL;Wang, SY;姚雅莉;Yao, Ya-Li;Yang, WM
贡献者:	生物科技學系
关键词:	Bromodomain;PCAF;STAF65γ;KAP1
日期:	2007-02
上传时间:	2012-11-23 09:10:31 (UTC+0)
摘要:	TRIP-Brs are a recently discovered set of proteins whose functions remain poorly characterized. Here we report the identification of TRIP-Br3 as a member of the TRIP-Br family along with evidence showing that TRIP-Brs interact with bromodomain-containing transcriptional cofactors PCAF, STAF65γ, and KAP1. PCAF, a histone acetyltransferase; STAF65γ, a protein associated with histone acetylation activity; and KAP1, a corepressor, influence the transcriptional activity of TRIP-Brs differentially. Finally, while all three TRIP-Brs are localized to the nucleus, TRIP-Br2 and TRIP-Br3 are also present in the cytoplasm through interaction with CRM1. Our results suggest that different TRIP-Brs function by interacting with a wide variety of bromodomain-containing transcriptional regulators in different subcellular locales.
關聯:	GENE,388(1-2),102–109.
显示于类别:	[生物科技學系] 期刊論文

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