Garlic oil attenuates the cardiac apoptosis in hamster-fed with hypercholesterol diet

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/16227

請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/16227

題名:	Garlic oil attenuates the cardiac apoptosis in hamster-fed with hypercholesterol diet
作者:	黃志揚;HUANG, CHIH-YANG
貢獻者:	生物科技學系
關鍵詞:	Garlic oil;Hypercholesterolemia;Cardiac apoptosis;Cardiac survival
日期:	2012
上傳時間:	2012-11-23 09:10:12 (UTC+0)
摘要:	Hypercholesterolemia is a well established risk factor for cardiac cell apoptosis. The purpose of this study is to evaluate the effects of garlic oil on cardiac apoptosis induced by a hypercholesterol diet. Twenty-four male Golden-Syrian hamsters at 3 months of age were randomly divided into three groups, control, cholesterol and garlic oil groups received a chow diet, chow diet with 2% cholesterol, and chow diet with 2% cholesterol and 1% garlic oil for 8 weeks, respectively. The TUNEL-positive apoptotic cells, and several apoptotic proteins were significantly induced in the excised left ventricle in cholesterol group, whereas significant reduction was observed in cholesterol plus garlic oil group. The IGFI receptor dependent survival pathway was inhibited in cholesterol group whereas it was obviously reversed in cholesterol plus garlic oil group. Our results suggest that administration of garlic oil shows protective effects on cardiac apoptosis in rats with high cholesterol intake.
關聯:	FOOD CHEMISTRY, V.136 N.3–4:1296–1302.
顯示於類別:	[生物科技學系] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	317	檢視/開啟

在ASIAIR中所有的資料項目都受到原著作權保護.