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http://asiair.asia.edu.tw/ir/handle/310904400/16224
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| Title: | Effects of exercise training on cardiac apoptosis in obese rats |
| Authors: | 黃志揚;HUANG, CHIH-YANG |
| Contributors: | 生物科技學系 |
| Date: | 2012 |
| Issue Date: | 2012-11-23 09:10:10 (UTC+0) |
| Abstract: | BACKGROUND AND AIM:
The purpose of this study was to evaluate the effects of exercise training on cardiac apoptotic pathways in obesity.
METHODS AND RESULTS:
Sixteen lean Zucker rats (LZR) and sixteen obese Zucker rats (OZR) of 5-6 months of age as well as the other sixteen obese rats were subjected to treadmill running exercise for 1 h everyday for 3 months (OZR-EX). After exercise training or sedentary status of the rats, the excised hearts from the three groups were measured by heart weight index, H&E staining, TUNEL assays and Western blotting. Cardiac TUNEL-positive apoptotic cells, the protein levels of TNF alpha, Fas ligand, Fas receptors, Fas-associated death domain (FADD), Bad, Bax, activated caspase 8, activated caspase 9, and activated caspase 3 were higher in OZR than those in LZR. The protein levels of TNF alpha, Fas ligand, Fas receptors, FADD, activated caspase 8, and activated caspase 3 (Fas pathway) and the protein levels of Bad, Bax, Bax-to-Bcl2 ratio, activated caspase 9, and activated caspase 3 (mitochondria pathway) were lower in OZR-EX than those in OZR.
CONCLUSION:
Cardiac Fas-dependent and mitochondria-dependent apoptotic pathways become more activated in obesity. Exercise training can prevent obesity-activated cardiac Fas-dependent and mitochondria-dependent apoptotic pathways. Our findings demonstrate a new therapeutic effect of exercise training to prevent delirious cardiac Fas-mediated and mitochondria-mediated apoptosis in obesity.
Copyright © 2011 Elsevier B.V. All rights reserved. |
| Relation: | Nutrition, Metabolism and Cardiovascular Diseases;23(6):566-73. |
| Appears in Collections: | [生物科技學系] 期刊論文
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