Solanum lyratum Extract Inhibits Helicobacter pylori-mediated Apoptosis in Human Gastric Epithelial Cells.

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Title:	Solanum lyratum Extract Inhibits Helicobacter pylori-mediated Apoptosis in Human Gastric Epithelial Cells.
Authors:	;Hsu, Yuan-Man;Lai, Chih-Ho;Su, Chiu-Hsiang;Kuo, Wei-Wen;Kuo, Chao-Lin;Hsu, Cheng-Kuang;王建國;Wang, Chien-Kuo;張清堯;Chang, Ching-Yao;鍾景光;Chung, Jing-Gung
Contributors:	生物科技學系
Keywords:	Helicobacter pylori;Solanum lyratum;human gastric epithelial cells;apoptosis
Date:	2010
Issue Date:	2012-11-23 09:09:29 (UTC+0)
Abstract:	Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.
Relation:	ANTICANCER RESEARCH, 30(4):1189-93
Appears in Collections:	[Department of Biotechnology] Journal Article

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