17b-Estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/16141

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題名:	17b-Estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells
作者:	;Lai, Tung-Yuan;Chen, Li-Mien;Lin, Jing-Ying;Tzang, Bor-Show;James, A.Lin;Tsai, Chang-Hai;Lin, Yueh-Min;黃志揚;HUANG, CHIH-YANG;Liu, Chung-Jung;Hsu, Hsi-Hsien
貢獻者:	生物科技學系
關鍵詞:	Estrogen-Prostaglandin E2-Human colon cancer cell-COX-2-Cell motility
日期:	2010
上傳時間:	2012-11-23 09:09:05 (UTC+0)
摘要:	Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular motility in human colon cancer cells. Upregulation of cyclooxygenase-2 (COX-2) is reported to associate with the development of cancer cell mobility, metastasis, and subsequent malignant tumor. After administration of inhibitors including LY294002 (Akt activation inhibitor), U0126 (ERK1/2 inhibitor), SB203580 (p38 MAPK inhibitor), SP600125 (JNK1/2 inhibitor), or QNZ (NFκB inhibitor), we found that PGE2 treatment increases COX-2 via Akt and ERK1/2 pathways, thus promoting cellular motility in human LoVo cancer cells. We further observed that 17β-estradiol treatment inhibits PGE2-induced COX-2 expression and cellular motility via suppressing activation of Akt and ERK1/2 in human LoVo cancer cells. Collectively, these results suggest that 17β-estradiol treatment dramatically inhibits PGE2-induced progression of human LoVo colon cancer cells.
關聯:	MOLECULAR AND CELLULAR BIOCHEMISTRY
顯示於類別:	[生物科技學系] 期刊論文

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