ASIA unversity:Item 310904400/16133
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    题名: Single Nucleotide Polymorphism of Exo1 Gene: Association with Gastric Cancer Susceptibility and Interaction with Smoking in Taiwan
    作者: Bau, Da-Tian;Wang, Hwei-Chung;Liu, Chiu-Shong;Chang, Chia-Lin;Chiang, Su-Yin;Wang, Rou-Fen;Tsai, Chia-Wen;Lo, Yen-Li;Chao, A.Hsiung;Lin, Cheng-Chieh;黃志揚;HUANG, CHIH-YANG
    贡献者: 生物科技學系
    关键词: Exo1;polymorphism;gastric cancer;carcinogenesis
    日期: 2009
    上传时间: 2012-11-23 09:08:58 (UTC+0)
    摘要: "Exonuclease 1 (Exo1) is an important nuclease involved in the mismatch repair system that
    contributes to the maintenance of genomic stability, modulation of DNA recombination and mediation
    of cell cycle arrest. Potential polymorphisms in Exo1 may alter cancer risks by influencing the repair
    activity of Exo1. We hypothesized that single-nucleotide polymorphisms (SNPs) in Exo1 might be
    associated with risks of gastric cancer. In this hospital-based study, the association of Exo1 A-1419G
    (rs3754093), C-908G (rs10802996), A238G (rs1776177), C498T (rs1635517), K589E (rs1047840), G670E
    (rs1776148), C723R (rs1635498), L757P (rs9350) and C3114T (rs851797) polymorphisms with gastric
    cancer risk in a central Taiwanese population was investigated. In total, 179 patients with gastric cancer
    and 179 age- and gender-matched healthy controls recruited from the China Medical Hospital in central
    Taiwan were genotyped. A significantly different distribution was found in the frequency of the Exo1
    K589E genotype, but not the other genotypes, between the gastric cancer and control groups. The A
    allele Exo1 K589E conferred a significant (P = 0.0094) increased risk of gastric cancer. Geneenvironment interactions with smoking were significant for Exo1 K589E polymorphism, which showed
    that the Exo1 K589E AG/AA genotype in association with smoking conferred an increased risk of 2.07-
    fold (95% confidence interval = 1.22-3.50) for gastric cancer. Our results provide the first evidence that
    the A allele of the Exo1 K589E may be associated with the development of gastric cancer and may be a
    novel and useful marker for primary prevention and anticancer intervention."
    關聯: CHINESE JOURNAL OF PHYSIOLOGY
    显示于类别:[生物科技學系] 期刊論文

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