Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague-Dawley rats.

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題名:	Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague-Dawley rats.
作者:	張竣維;Hebron, C.Chang;Daniel R. Doerge;Mona I. Churchwell;Retha R. Newbold;K.Barry Delclos
貢獻者:	生物科技學系
關鍵詞:	Soy;Isoflavones;Genistein;Placental transfer;Mass spectrometry
日期:	2001
上傳時間:	2012-11-23 09:08:04 (UTC+0)
摘要:	Genistein, the principal soy isoflavone, has estrogenic activity and is widely consumed by humans for putative beneficial health effects. The goal of the present study was to measure placental transfer of genistein in rats as a possible route of developmental exposure. Pregnant Sprague-Dawley rats were administered genistein orally, either by diet or by gavage. Concentrations of genistein aglycone and conjugates were measured in maternal and offspring serum and brain using HPLC with isotope dilution electrospray tandem mass spectrometry. Although fetal or neonatal serum concentrations of total genistein were approximately 20-fold lower than maternal serum concentrations, the biologically active genistein aglycone concentration was only 5-fold lower. Fetal brain contained predominately genistein aglycone at levels similar to those in the maternal brain. These studies show that genistein aglycone crosses the rat placenta and can reach fetal brain from maternal serum genistein levels that are relevant to those observed in humans.
關聯:	REPRODUCTIVE TOXICOLOGY,15(2),105–110.
顯示於類別:	[生物科技學系] 期刊論文

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