Purpose: It is assumed that hospice nurses with religiosity and spirituality should have a higher level of hospice care efficacy. In Taiwan, however, the religious affiliation is not easy to be identified due to the religious plurality. Material and Method: In this study, a measurement is applied to assess both the preliminary and confirmatoryresponses of one's religious affiliation. One hundred and ninety-five hospice nurses around Taiwan gave responses to the assessments of this study. Results: It was found that, compared to the preliminary inquiry, quite a number of hospice nurses changed their religious identity in the secondary inquiry. In specific, the number of Buddhist and folk religion believers increased while the number of non-believers decreased. Subsequent analyses reveal the fact that data of the preliminary inquiry of religious identity was not able to predict one's level of hospice care efficacy. On the contrary, hospice nurses' secondary response predicted significantly their hospice care efficacy. In specific, the Buddhists and the non-believers had significantly higher level of hospice efficacy than the folk religion believers. It is discussed that hospice nurses should get a clear identification and understanding of their religious affiliations. Conclusion: It is also essential that various doctrine components that would facilitate or hinder the level of hospice care efficacy should be duly noted.