ASIA unversity:Item 310904400/15871
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    ASIA unversity > 醫學暨健康學院 > 心理學系 > 期刊論文 >  Item 310904400/15871


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    題名: MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence.
    作者: Sheng-Yu Lee;Cheng-Yi Hahn;Jia-Fu Lee;San-Yuan Huang;Shiou-Lan Chen;Po-Hsiu Kuo, I Hui Lee;Tzung Lieh Yeh;Yen Kuang Yang;Shih-Heng Chen;Huei-Chen Ko;Ru-Band Lu
    貢獻者: 心理學系
    日期: 2010
    上傳時間: 2012-11-23 07:03:34 (UTC+0)
    摘要: BACKGROUND:
    Alcohol dependence is usually comorbid with anxiety disorder, depressive disorder, or both; this comorbidity may increase drinking behavior. We previously hypothesized that anxiety-depressive alcohol dependence (ANX/DEP ALC) was a genetically specific subtype of alcohol dependence. ANX/DEP ALC may be related to dopamine and serotonin, which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). The aim of this study was to determine whether the interaction between the MAOA and the ALDH2 genes is associated with ANX/DEP ALC.
    METHODS:
    We recruited 383 Han Chinese men in Taiwan: 143 ANX/DEP ALC and 240 healthy controls. The diagnosis of ANX/DEP ALC (alcohol dependence with a past or current history of anxiety, depressive disorder, or both) was made using DSM-IV criteria. Genotypes of ALDH2 and MAOA-uVNTR (variable number of tandem repeat located upstream) were determined using PCR-RFLP.
    RESULTS:
    The ALDH2, but not the MAOA-uVNTR, polymorphism was associated with ANX/DEP ALC. After stratifying the MAOA-uVNTR polymorphism, we found a stronger association between the ALDH2*1/*2 and *2/*2 genotypes and the controls in the MAOA-uVNTR 4-repeat subgroup. Logistic regression significantly associated the interaction between ALDH2 and MAOA variants with ANX/DEP ALC.
    CONCLUSION:
    We conclude that the MAOA and ALDH2 genes interact in ANX/DEP ALC. Although the MAOA gene alone is not associated with ANX/DEP ALC, we hypothesize that different variants of MAOA-uVNTR polymorphisms modify the protective effects of the ALDH2*2 allele on ANX/DEP ALC in Han Chinese in Taiwan.
    關聯: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 34(7):1212-1218.
    顯示於類別:[心理學系] 期刊論文

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