Retinopathy is the most common complication in type 2 diabetes. Many people usually will get diabetic retinopathy when they have diabetic type 2. In Taiwan the incidence of type 2 diabetes is high, so the retinopathy prone to happen in these persons and finally might lead to blindness in the productive age. Fenofibrate is a drug for lipid control by lowering the lipid. In this research, based on the data from National Health Insurance Research Database, I study the association of using fenofibrate and the risk of retinopathy in type 2 diabetes. The results are significant because 95%CI does not include 1 and the HR is less than one, so the risk of retinopathy is low. From adjusted variable of gender (HR=0.82; 95%CI= 0.71-0.95), age (HR=0.81; 95%CI= 0.70-0.94), sex and age (HR=0.81; 95%CI= 0.70-0.94) and for not adjusted variable it obtained (HR=0.82; 95%CI= 0.71-0.95).