Studies On The Reproductive, Developmental Toxicity And Endocrine Disrupting Activity Induced By Carbendazim And Its Precursor Benomyl In Multiple Generation Of Rats.

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Title:	Studies On The Reproductive, Developmental Toxicity And Endocrine Disrupting Activity Induced By Carbendazim And Its Precursor Benomyl In Multiple Generation Of Rats.
Authors:	Chen, Jing-Huei
Contributors:	Department of Biotechnology Shui-Yuan Lu;Ching-Yao Chang
Keywords:	endocrine disrupting activity;developmental toxicity;reproductive toxicity;benomyl;Carbendazim
Date:	2012
Issue Date:	2012-11-18 08:04:32 (UTC+0)
Publisher:	Asia University
Abstract:	Both carbendazim and benomyl are antifungal benzimidazole compounds used to control fungal and bacterial proliferation on a large variety of crops. The previous reports showed that they induced reproductive and developmental toxicities and endocrine disrupting activity in rats. However, there is no clear answer on the effect of them on multi-generation of rats. This study was conducted to investigate the effect of them on reproductive and developmental toxicities and endocrine disrupting activity from the first to the fourth generation of rats. Maternal rats were treated with 0 (corn oil), 6.25, 12.5, 25 and 50 mg/kg/day carbendazim or benomyl by gavage once daily from day 0 to 20. The offspring was rear to puberty and mated with male or female from different dose group. Based on the principle F1-F4 was produced. In general, carbendazim and benomyl increased the male and female pup weight in F1-F4. Also, they increased the tissue weight of testis, epididymis, prostate and seminal vesicle. Although they increased the tissue weight, later they decreased the tissue weight. This might be the process of tissue from edema to atrophy induced by carbendazim and benomyl. There is no obvious effect on reproductive tissue of female rats in F1-F4. The anogenital distance including anus-penis,anus-vagina, vagina-urethra, and anus-urethra were increased in F1-F4. The body weight after puberty in male and female were increased except F1. The androgen receptor expression in the testis, epididymis and prostate were not significant in F1-F4. By the way 6.25 mg/kg/day carbendazim produced the neuropathy offspring in F3. This might be speculated that carbendazim and benomyl disrupted the androgen receptor and resulted in the spinal muscular atrophy (SMA). Based on the above,this study inferred that carbendazim and benomyl might disrupt androgen receptor and increase reproductive organ weight, anogenital distance, pup weight and body weight after puberty.These indicators might explain that androgen receptor disrupting led to the masculinization, obesity and neuropathology.
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