Cinnamaldehyde has been used frequently in medical treatment, some researches indicated that Cinnamaldehyde can use as antimicrobial and antifungal. There are two main goals in our study. One is to characterize Cinnamaldehyde’s ability to inhibit tyrosinase, the other is to screen it’s antibacterial activity. We encapsulated Cinnamaldehyde through hydroxypropyl-β-cyclodextrin (hp-β-CD) by molecular inclusion, and the resulting Cinnamaldehyde complex could release it’s content with time. Furthermore, the results of antibacterial test also demonstrated that the activity of Cinnamaldehyde against Gram-positive bacteria were related to the content of Cinnamaldehyde complex. The formations of hp-β-CD Cinnamaldehyde complex were characterized by differential canning calorimetry (DSC), thermo-gravimetric analysis (TGA), TLC ,UV , NMR. The minimum inhibitory concentration (MIC) of Cinnamaldehyde complex defined as the lowest concentration is able to inhibit visible microbial growth, and minimum bactericidal concentration (MBC) is the lowest concentration of needed to kill of the bacteria. Both MIC and MBC were determined by using the broth serial dilution method and plating on agar. According to our results, hp-β-CD Cinnamaldehyde complex is a strongly tyrosinase inhibitor and useful for antibacterial, demonstrating that hp-β-CD Cinnamaldehyde complex exhibits good propert ies and potential on treating clinical treatment.
