| Abstract: | 銅藻（Sargassum Horneri）是一種溫帶性海洋大型褐藻，廣泛分布於中國、韓國和日本沿海等地區。由於台灣處於副熱帶氣候地區，因此並沒有在地的野生銅藻。但是，漂流性銅藻在冬末春初大陸沿岸冷流來到時，會順著冷水團渡過台灣海峽，來到台灣的中、北部海岸及澎湖海岸，成為台灣海洋的廢棄物，甚至造成漁船故障、近海的魚貝類受困死亡，海岸惡臭的環境問題。雖然大量漂流來的銅藻帶來了海洋問題，但銅藻所含有的褐藻醣膠具有多種生物活性，如抗菌、抗氧化、抗病毒、抗炎、抗腫瘤、抗凝血和免疫調節活性等功能。有鑑於褐藻醣膠具有調節與傷口修復相關的轉化生長因子β1的作用，並且能促進新生血管和纖維狀膠原基質的形成等幫助皮膚修復的潛力。因此，本研究結合過去在開發人工真皮的經驗，將台灣海岸銅藻所萃取的褐藻醣膠應用於全皮膚損傷修復之三維海綿敷料的開發。本研究目前已開發含褐藻醣膠的三維海綿敷料的製程及配比，及評估其物理性質及生物相容性。未來將進行組織學及皮膚組織修復能力結果評估。本研究將台灣海域銅藻萃取之褐藻醣膠應用於傷口敷料開發將有助於提升傷口醫療修復的發展，並且幫助提升銅藻的經濟價值，及解決銅藻成為海洋廢棄物的問題。
Sargassum Horneri is a temperate marine macroalgae widely distributed in coastal areas of China, Korea and Japan. Because Taiwan is in a subtropical climate area, there are no wild copper algae in the area. However, the drifting copper algae will cross the Taiwan Strait along the cold water mass when the cold current comes along the coast of the mainland in late winter and early spring, and come to the central and northern coasts of Taiwan and the coast of Penghu. Although a large number of drifting copper algae has brought marine problems, the fucoidan contained in copper algae has a variety of biological activities, such as antibacterial, antioxidant, antiviral, anti-inflammatory, antitumor, anticoagulant and immunomodulatory activities. In view of the potential of fucoidan to regulate transforming growth factor β1 related to wound repair, and to promote the formation of new blood vessels and fibrous collagen matrix, etc., to help skin repair. Therefore, in this study, combined with the experience in the development of artificial, fucoidan extracted from Taiwan's coastal copper algae was used to evaluate the development of a three-dimensional sponge dressing for the repair of total skin damage. In this study, the manufacturing process and proportion of the three-dimensional sponge dressing containing fucoidan have been developed, and its physical properties and biocompatibility have been evaluated. In the future, histological and skin tissue capacity repair results will be evaluated. In this study, the development of fucoidan and dressings extracted from copper algae along the coast of Taiwan will help to improve the development of medical repair, and help to increase the economic value of copper algae, and solve the problem of copper algae being discharged into the ocean. |
