A concise partial synthesis of microporenic acid A, a natural product showcasing potential cytotoxicity and antimicrobial activity, was proposed. The synthetic route features a facile synthesis of isocitric acid segment prepared from (R)-malic acid, and a strategic utilization of farnesyl acetone to make the diterpene unit. This synthesis represents a firm basis for the preparation of divergent kinds of microporenic acids A-G for future studies.
