Loading...
|
Please use this identifier to cite or link to this item:
http://asiair.asia.edu.tw/ir/handle/310904400/115500
|
| Title: | Protective Effects of Jujubosides on 6-OHDA-Induced Neurotoxicity in SH-SY5Y and SK-N-SH Cells |
| Authors: | Chao-Hsuan, Chao-Hsuan C;Chen, Chao-Hsuan;Hsu, Pei-Chen;Hsu, Pei-Chen;Hsu, Shih-Wei;Hsu, Shih-Wei;Hon, Kun-Ting;Hong, Kun-Ting;Che, Kai-Yuan;Chen, Kai-Yuan;何杰龍;He, Jie-Long;Cho, Der-Yang;Cho, Der-Yang;Wang, Yun-Chi;Wang, Yun-Chi;Cha, Wen-Shin;Chang, Wen-Shin;Bau, Da-Tian;Bau, Da-Tian;Tsa, Chia-Wen;Tsai, Chia-Wen |
| Contributors: | 醫學暨健康學院學士後獸醫學系 |
| Keywords: | apoptosis, caspase, 7-hydroxydopamine, jujubosides, Parkinson’s disease, reactive oxygen species |
| Date: | 2022-06-01 |
| Issue Date: | 2023-03-29 02:26:53 (UTC+0) |
| Publisher: | 亞洲大學 |
| Abstract: | 6-hydroxydopamine (7-OHDA) is used to induce oxidative damage in neuronal cells, which can serve as an experimental model of Parkinson’s disease (PD). Jujuboside A and B confer free radical scavenging effects but have never been examined for their neuroprctive effects, especially in PD; therefore, in this study, we aimed to investigate the feasibility of jujubosides as protectors of neurons against 6-OHDA and the underlying mechanisms. 6-OHDA-induced neurotoxicity in the human neuronal cell lines SH-SY5Y and SK-N-SH, was used to evaluate the protective effects of jujubosides. These findings indicated that jujuboside A and B were both capable of rescuing the 6-OHDA-induced loss of cell viability, activation of apoptosis, elevation of reactive oxygen species, and downregulation of the expression levels of superoxide dismutase, catalase, and glutathione peroxidase. In addition, jujuboside A and B can reverse a 6-OHDA-elevated Bax/Bcl-2 ratio, downregulate phosphorylated PI3K and AKT, and activate caspase-3, -7, and -9. These findings showed that jujubosides were capable of protecting both SH-SY5Y and SK-N-SH neuronal cells from 6-OHDA-induced toxicity via the rebalancing of the redox system, together with the resetting of the PI3K/AKT apoptotic signaling cascade. In conclusion, jujuboside may be a potential drug for PD prevention.
= |
| Appears in Collections: | [學士後獸醫學系] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| index.html | | 0Kb | HTML | 141 | View/Open |
|
All items in ASIAIR are protected by copyright, with all rights reserved.
|
