The Effectiveness of Fuzi in Combination with Routine Heart Failure Treatment on Chronic Heart Failure Patients

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Title:	The Effectiveness of Fuzi in Combination with Routine Heart Failure Treatment on Chronic Heart Failure Patients
Authors:	Tai, Chi-Jung;Tai, Chi-Jung;Mohamed, El-S;Mohamed, El-Shazly;Yang, Yi-Hsin;Yang, Yi-Hsin;Tsai, Yi-Hong;Tsai, Yi-Hong;Csupor, Dezs?;Csupor, Dezs?;Hohman, Judit;Hohmann, Judit;吳永昌;Wu, Yang-Chang;Ts, Tzyy-Guey;Tseng, Tzyy-Guey;Ch, Fang-Rong;Chang, Fang-Rong;Wan, Hui-Chun;Wang, Hui-Chun
Contributors:	醫學暨健康學院醫學檢驗暨生物技術學系
Keywords:	Aconitum;Fuzi;Heart failure;Propensity-score matching;Restricted cubic spline.
Date:	2022-01-01
Issue Date:	2023-03-29 02:24:43 (UTC+0)
Publisher:	亞洲大學
Abstract:	Ethnopharmacological relevance: Fuzi, Aconiti Lateralis Radix Praeparata, is widely used in Traditional Chinese Medicine (TCM) for the treatment of acute heart failure (HF) for 2000 years. However, the clinical evidence of Fuzi in the treatment of chronic HF is limited, especially when used in combination with Western medications. Materials and methods: This population-based propensity score (PS)-matched cohort study aimed to evaluate the effectiveness of Fuzi on the chronic HF. From 4753 chronic HF patients who had used TCM herbal medicine, we performed 1:1 PS matching and selected target patients with (n = 921) and without (n = 921) Fuzi use for further analysis. The primary outcomes were all-cause mortality and composite cardiovascular (CV) outcomes. Hazard ratio (HR) was calculated by Cox proportional hazard regression and the competing risk analysis. The dose-response relationship and the association between the initiation of TCM herbal medicine and the primary outcomes were evaluated by restricted cubic spline (RCS) functions. Results: There was no difference in all-cause mortality (HR, 0.99; 95% confidence interval [CI], 0.76-1.27) and composite CV outcomes (HR, 0.96; 95% CI, 0.84-1.11) between the Fuzi user and non-user groups. For CV safety issue, the result showed that Fuzi use was not associated with a higher risk of cardiac arrhythmias (HR, 1.03; 95% CI, 0.83-1.29). The dose-response relationship showed that Fuzi cumulative dose (?150g) was associated with lower composite CV risk (HR, 0.76; 95% CI, 0.59-0.99). In addition, the RCS model showed that late initiation (?2.5 years) of TCM herbal drugs in chronic HF patients had a higher risk of all-cause mortality (HR, 1.81; 95%CI, 1.07-3.08). Conclusions: This study is the first real-world evidence to demonstrate the effect of Fuzi combined with routine HF treatment. Importantly, the result indicated that long-term Fuzi use had a significant benefit in preventing cardiovascular events. The late initiation of TCM herbal drugs was associated with a higher risk of all-cause mortality. Further clinical trials are needed to support or undermine the assumption of using Fuzi and current Western medications to treat chronic HF.
Appears in Collections:	[Department of Biotechnology] Journal Article

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