Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/115438

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题名:	Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders
作者:	Marthandam, A;Shibu, Marthandam Asokan;Lin, Yu-Jung;Lin, Yu-Jung;Chi, Chien-Yi;Chiang, Chien-Yi;Lu, Cheng-You;Lu, Cheng-You;Go, Debakshee;Goswami, Debakshee;Navaneethan;Sundhar, Navaneethan;Agarw, Surbhi;Agarwal, Surbhi;Md, Nazmul I;Islam, Md. Nazmul;Lin, Pi-Yu;Lin, Pi-Yu;Shinn-Zong, L;Lin, Shinn-Zong;黃志揚;Huang, Chih-Yang
贡献者:	醫學暨健康學院醫學檢驗暨生物技術學系
关键词:	Aging;Cardiac diseases;Diabetes;Homeostasis;Multitarget drugs;Oncogenesis;Self-renewal;Stemness.
日期:	2022-01-01
上传时间:	2023-03-29 02:23:24 (UTC+0)
出版者:	亞洲大學
摘要:	Common characteristics of aging include reduced somatic stem cell number, susceptibility to cardiac injuries, metabolic imbalances and increased risk for oncogenesis. In this study, Pleiotropic anti-aging effects of a decoction Jing Si herbal drink (JS) containing eight Traditional Chinese Medicine based herbs, with known effects against aging related disorders was evaluated. Adipose derived mesenchymal stem cells (ADMSCs) from 16 week old adult and 24 month old aging WKY rats were evaluated for the age-related changes in stem cell homeostasis. Effects of JS on self-renewal, klotho and Telomerase Reverse Transcriptase expression DNA damage response were determined by immunofluorescence staining. The effects were confirmed in senescence induced human ADMSCs and in addition, the potential of JS to maintain telomere length was evaluated by qPCR analysis in ADMSCs challenged for long term with doxorubicin. Further, the effects of JS on doxorubicin-induced hypertrophic effect and DNA damage in H9c2 cardiac cells; MPP+-induced damages in SH-SY5Y neuron cells were investigated. In addition, effects of JS in maintaining metabolic regulation, in terms of blood glucose regulation in type-II diabetes mice model, and their potential to suppress malignancy in different cancer cells were ascertained. The results show that JS maintains stem cell homeostasis and provides cytoprotection. In addition JS regulates blood glucose metabolism, enhances autophagic clearances in neurons and suppresses cancer growth and migration. The results show that JS acts on multiple targets and provides a cumulative protective effect against various age-associated disorders and therefore it is a candidate pleiotropic agent for healthy aging.
显示于类别:	[生物科技學系] 期刊論文

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