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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/115437


    Title: Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats
    Authors: Li, Jing?Ying;Lin, Jing?Ying;Chi?Ka, Bruce;Tsai, Bruce Chi?Kang;Ka, Hui?Chuan;Kao, Hui?Chuan;Chi, Chien?Yi;Chiang, Chien?Yi;Chen, Yun?An;Chen, Yun?An;Shao, William;Chen, William Shao?Tsu;Tsung?Jung, H;Ho, Tsung?Jung;Yao, Chun?Hsu;Yao, Chun?Hsu;Kuo, Wei?Wen;Kuo, Wei?Wen;黃志揚;Huang, Chih-Yang
    Contributors: 醫學暨健康學院醫學檢驗暨生物技術學系
    Keywords: Diabetic mellitus;Hyperglycemia;Lactic acid bacteria;Lactobacillus reuteri;Streptozotocin.
    Date: 2022-08-01
    Issue Date: 2023-03-29 02:23:22 (UTC+0)
    Publisher: 亞洲大學
    Abstract: Diabetes-related brain complications have been reported in clinical patients and experimental models. The objective of the present study was to investigate the neuroprotective mechanisms of Lactobacillus reuteri GMNL-263 in streptozotocin (STZ)-induced diabetic rats. In this study, three different groups, namely control group, STZ-induced (55 mg/kg streptozotocin intraperitoneally) diabetic rats (DM), and DM rats treated with Lactobacillus reuteri GMNL-263 (1 × 109 CFU/rat/day), were utilized to study the protective effect of GMNL-263 in the hippocampus of STZ-induced diabetic rats. The results demonstrated that GMNL-263 attenuated diabetes-induced hippocampal damage by enhancing the cell survival pathways and repressing both inflammatory and apoptotic pathways. Histopathological analysis revealed that GMNL-263 prevented structural changes in the hippocampus in the DM group and decreased the level of inflammation and apoptosis in the hippocampus of DM rats. The IGF1R cell survival signaling pathway also improved after GMNL-263 treatment. These results indicate that probiotic GMNL-263 exerts beneficial effects in the brain of diabetic rats and has potential ability for clinical application.
    Appears in Collections:[生物科技學系] 期刊論文

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