How mycobacterium tuberculosis infection could lead to the increasing risks of chronic fatigue syndrome and the potential immunological effects: a population?based retrospective cohort study

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/115425

請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/115425

題名:	How mycobacterium tuberculosis infection could lead to the increasing risks of chronic fatigue syndrome and the potential immunological effects: a population?based retrospective cohort study
作者:	楊哲彥;Yang, Tse-Yen Kenny;Lin, Cheng-Li;Lin, Cheng-Li;Ya, Wei-Cheng;Yao, Wei-Cheng;Lio, Chon-Fu;Lio, Chon-Fu;Chian, Wen-Po;Chiang, Wen-Po;Lin, Kuan;Lin, Kuan;Chien-Feng, K;Kuo, Chien-Feng;Tsai, Shin-Yi;Tsai, Shin-Yi
貢獻者:	醫學暨健康學院醫學檢驗暨生物技術學系
關鍵詞:	Chronic fatigue syndrome (CFS);Immunological effect;Mycobacterium tuberculosis infection (MTI);Population-based retrospective cohort study;Risk factors.
日期:	2022-02-01
上傳時間:	2023-03-29 02:22:48 (UTC+0)
出版者:	亞洲大學
摘要:	Background: Chronic fatigue syndrome (CFS) has been shown to be associated with infections. Tuberculosis (TB) is a highly prevalent infectious disease. Patients with chronic fatigue syndrome and post-tuberculosis experience similar symptoms. Furthermore, chronic fatigue syndrome and tuberculosis share similar plasma immunosignatures. This study aimed to clarify the risk of chronic fatigue syndrome following the diagnosis of Mycobacterium tuberculosis infection (MTI), by analyzing the National Health Insurance Research Database of Taiwan. Methods: 7666 patients aged 20 years or older with newly diagnosed Mycobacterium tuberculosis infection during 2000-2011 and 30,663 participants without Mycobacterium tuberculosis infection were identified. Both groups were followed up until the diagnoses of chronic fatigue syndrome were made at the end of 2011. Results: The relationship between Mycobacterium tuberculosis infection and the subsequent risk of chronic fatigue syndrome was estimated through Cox proportional hazards regression analysis, with the incidence density rates being 3.04 and 3.69 per 1000 person-years among the non-Mycobacterium tuberculosis infection and Mycobacterium tuberculosis infection populations, respectively (adjusted hazard ratio [HR] = 1.23, with 95% confidence interval [CI] 1.03-1.47). In the stratified analysis, the Mycobacterium tuberculosis infection group were consistently associated with a higher risk of chronic fatigue syndrome in the male sex (HR = 1.27, 95% CI 1.02-1.58) and age group of ? 65 years old (HR = 2.50, 95% CI 1.86-3.38). Conclusions: The data from this population-based retrospective cohort study revealed that Mycobacterium tuberculosis infection is associated with an elevated risk of subsequent chronic fatigue syndrome.
顯示於類別:	[生物科技學系] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	53	檢視/開啟

在ASIAIR中所有的資料項目都受到原著作權保護.

資料載入中.....